existential acrobat

Saturday, December 29, 2012

New Year Detox Promise ? ecnbodyworks

How To Banish The Bloating

Hey I hope you have all had a fabulous Xmas??

On boxing day I released my 7 day detox plan to help you all get the new year started as you mean to go on.

I don?t know about you but my energy levels have taken a massive dive since I started to eat more of the stuff I wouldn?t usually.? This involves more drinking, more chocolate and sweeties, in fact just all the things we really know we shouldn?t.

You know what, I have thoroughly enjoyed it but I wouldn?t want to feel like this all the time. Today the studio was open for a Kettlebell session and it felt so good to get back to doing some proper exercise, I really felt like I needed it.

You see that is the difference I will not feel guilty about enjoying the foods and drinks that I want to because I know that I will also look forward to getting back to being healthy. The feeling of being fit and healthy far outweighs what I?m feeling right now.

That is one of the main reasons I am looking forward to joining you on the 7 day detox. It starts on the 1^st but I will be joining in on the 7^th.

I have been hearing in the news today about the government not wanting to promote dieting in the new year as it is irresponsible. In? a way I agree as there are a lot of very bad eating plans out there, like eating a certain cereal twice a day and then a meal for dinner is never going to be a good lifestyle choice.

You cannot get your daily needs for vitamins and minerals from this type of diet. When you body is left deficient from essential vitamins and minerals it will always be left craving what it needs to survive. For that reason any weight loss on this style of diet will be temporary and in fact you will probably end up gaining more back.

When choosing your eating plan you should always look for something that focuses on health. ALWAYS make your health your top priority. Choose health and weight loss if just a good by product of good health.

As long as you are looking towards health, then why not use the new year as a time when you set out to make changes to your life.

Change your focus from weight loss to improving your health, don?t look at it as a diet but long term changes that you plan on sticking with for life!!!

Do that and your weight loss and your energy levels will change dramatically.

I?m serious why look at improving health for a short period of time?? Why would you not want to look and feel better for life??

If you want to learn how to improve your health but are not too sure where to start, come and and get on board with the ?7 day detox.

Here is the perfect solution to help u kick start your detox on January the 1st.

Lose up to 7lb in 7 days with our 7 day detox

7 Breakfast Smoothies (perfect for busy mornings!)

7 Protein Packed Lunches (can be eaten hot or cold, again perfect if you are on the go)

7 Hot Healthy Dinners (that can be prepared in under 30 minutes)

All for just ?7

You also get a digital flip book version which is great on iphone or other tablet for quick and easy access

Remember though start as you mean to go on.

We will not only give you the detox recipies and information, you will also get access to our private Facebook support group should you have any questions along the way.

Click here for more information and booking

http://blackpoolbootcamp.com

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Source: http://fitnessblackpool.com/2012/12/27/new-year-detox-promise/

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Friday, December 28, 2012

Enable a Hidden Topographical Layer in Google Maps on Jailbroken iPhones

Enable a Hidden Topographical Layer in Google Maps on Jailbroken iPhones iOS (jailbroken): Google's new Maps app for iOS is pretty great, but it has one hidden feature that makes it even better. Here's how to enable hidden topographical maps on your jailbroken iPhone.

This tweak was discovered by iOS developer Ryan Petrich, so you'll need to enable his repository to install the tweak. Just open up Cydia and head to Manage > Sources, then add http://rpetri.ch/repo/ as a new source. After refreshing Cydia, you should be able to find it by searching for "Topography for Google Maps" in Cydia.

Once enabled, open up Google Maps and open the drawer on the right. You should see a new "Topography" option at the bottom, which gives you a more Google Earth-eque view. We aren't sure why Google left this disabled, but we assume there may still be a few bugs with it, so use at your own risk.

So Google's new Maps app has a hidden topography mode? | @rpetrich via Cult of Mac

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/V0kyulz3FkM/enable-a-hidden-topographical-layer-in-google-maps-on-jailbroken-iphones

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It's husband No. 3 for actress Kate Winslet

FILE - In this Tuesday, March, 27, 2012, file photo, British actress Kate Winslet arrives at the World Premiere of Titanic 3D at the Royal Albert Hall in London. Winslet married Ned Rocknrol in New York in December 2012. The private ceremony was attended by Winslet's two children as well as a few friends and family members, her representative said Thursday, Dec. 27, 2012. It is the third marriage for the 37-year-old Winslet. (AP Photo/Alastair Grant, File)

NEW YORK (AP) ? Kate Winslet has tied the knot again.

The Oscar-winning actress wed Ned Rocknroll in New York earlier this month. The private ceremony was attended by Winslet's two children as well as a few friends and family members, her representative said Thursday.

It is the third marriage for the 37-year-old Winslet. She was previously married to film directors Jim Threapleton and Sam Mendes.

The 34-year-old Rocknroll, who was born Abel Smith, is a nephew of billionaire Virgin Group founder Richard Branson.

The couple had been engaged since last summer.

Winslet won a Best Actress Oscar for her performance in the 2008 film "The Reader."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-12-27-People-Kate%20Winslet/id-62db28ab8a014b0ab1155f9a572f8d51

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County property insurance increases by $100K | CJOnline.com

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Source: http://cjonline.com/news/2012-12-27/county-property-insurance-increases-100k

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UN envoy, Moscow call for revival of Syria plan

In this image taken from video obtained from the Shaam News Network, which has been authenticated based on its contents and other AP reporting, smoke rises from buildings from heavy shelling in Damascus, Syria, on Thursday, Dec. 27, 2012. (AP Photo/Shaam News Network via AP video)

In this image taken from video obtained from the Shaam News Network, which has been authenticated based on its contents and other AP reporting, smoke rises from buildings from heavy shelling in Homs, Syria, on Thursday, Dec. 27, 2012. (AP Photo/Shaam News Network via AP video)

BEIRUT (AP) ? Russia and the U.N called Thursday for the resuscitation of a peace initiative for Syria that never got off the ground when it was proposed months ago because both parties to the conflict rejected it.

The plan, unveiled by world powers at an international conference in Geneva in June, called for an open-ended cease-fire, a transitional government to run the country until elections, and the drafting of a new constitution. The plan was a non-starter for the opposition because it did not explicitly ban authoritarian President Bashar Assad and other members of his regime from taking part in the transitional leadership.

The regime ignored it because it would entail voluntarily giving up power.

There was no sign that the plan had any more chance of succeeding now than it did back in June. Assad's government did not comment on the attempt to revive the proposal, and a coordinator for the rebels seeking to end Assad's rule called the plan "illogical."

"No one in the opposition can accept this, and if they accept it, it will be refused by the Syrian people," said Bassam Al-Dada, a Turkey-based coordinator with the rebel Free Syrian Army. He said Assad's forces have killed too many people for him to play a role in any solution.

Anti-regime activists say more than 40,000 people have been killed since the revolt against Assad began in March 2011.

Because of Russian objections, the original plan did not call specifically for Assad's ouster nor ban him or top members of his regime from participating in the new government.

Much has changed in Syria since the plan was first presented. Rebels have gained momentum, seizing more territory and a number of military installations in the country's north. They are also expanding their control in suburbs of the capital, Damascus.

These gains make it increasingly unlikely that they will accept any plan that allows any part of Assad's regime to remain.

The government, too, has given no indication it will give any ground and dismisses almost all opposition activities as terrorism that seeks to destroy the country.

In Damascus on Thursday, the U.N. envoy for Syria Lakhdar Brahimi called the Geneva plan "suitable enough" to end Syria's war.

"The Syrian people seek genuine change," Brahimi said, adding that the transitional period "must not lead to the collapse of the state or the state's institutions."

Brahimi said that original plan could be amended, but he didn't say how.

He did not mention Assad by name and only said the transitional government would have "full executive powers," meaning "all the authority of the state should be possessed by that government."

Brahimi said it remained to be determined what kind of government would follow and whether the elections called for under the plan would be for president or parliament.

In Moscow, Foreign Ministry spokesman Alexander Lukashevic said Russia, too, is trying to revive the Geneva plan.

"We continue to believe that there is no alternative to that document in trying to find a settlement in Syria," Lukashevich said.

He also reaffirmed Moscow's objection to calls for Assad's ouster.

Russia has been Assad's strongest backer throughout the conflict, selling arms to his forces and, along with China, protecting him from censure by the U.N. Security Council for his violent crackdown on the opposition.

Top Russian officials have recently signaled a new resignation to the idea that Assad could fall. Still, they have said they will not call for his ouster or offer him refuge should he decide to flee.

Brahimi is expected to visit Russia this weekend. Syrian Deputy Foreign Minister Faisal Mekdad met Thursday with Russia's Foreign Minister Sergey Lavrov to pave the way for Brahimi's visit.

Mekdad is expected to hold talks with other top Russian diplomats later.

Violence flared in Syria again on Thursday, with rebels attacking a police academy and military airport in the northern province of Aleppo while clashing with government forces near the Wadi Deif military base in northern Idlib province.

The Britain-based Syrian Observatory for Human Rights said 11 rebels and 16 government soldiers were killed in clashes around Idlib province.

A car bomb blew up in the Damascus suburb of Sbeineh, killing four people and wounding ten, the state news agency reported.

___

Associated Press writers Albert Aji in Damascus, Syria, and Vladimir Isachenkov Moscow contributed reporting.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-12-27-ML-Syria/id-452f0596b06140ac9a8aec63c7cd1175

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Mimicking a natural defense against malaria to develop new treatments

Dec. 27, 2012 ? One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease.

Their work was published in this months' issue of Cell Host and Microbe.

Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.

"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.

While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have similar beneficial effects against the Plasmodium parasite. After screening approximately 2000 small molecule HDP mimics (smHDPs) developed by biotech company PolyMedix, Inc. of Radnor, PA, Greenbaum and his team found that "all of the best hits had the same mechanism of action against Plasmodium parasites."

Like the natural hPF4 found in platelets, the most effective smHDPs tested targeted only infected red blood cells, attacking and destroying the parasite in exactly the same way, but with even greater potency and speed. "The smHDPs get into infected red cells and lyse or basically destroy the digestive vacuole or stomach of the parasite more rapidly than the hPF4 protein," Greenbaum notes. "The protein from platelets is about 25 times less potent, but the surprising thing is they act with the same mechanism. With ease, within seconds, they destroy the vacuole of the parasite."

Greenbaum's team settled on two compounds, PMX1207 and PMX207, for testing in mouse models of malaria. Both compounds significantly decreased parasitic growth and greatly improved survival rates, providing further confirmation of the potential of smHDPs as antimalarial agents. The work, Greenbaum says, shows that "we can translate a natural arm of the innate immune system in platelets to drug-like small molecules that we are honing to become potent, selective, potentially less toxic, and cheaper to make as an antimalarial."

Aside from their great effectiveness, smHDPs may have several other advantages over other antimalarial therapies. As Plasmodium inevitably adapts and becomes resistant to a particular drug therapy, the efficacy of that treatment decreases and survival rates drop. By mimicking the body's own natural defenses, the new HDP-centered approach could avoid that pitfall. "Certainly with malaria we've had a lot of problems in the last 20 years with resistance," Greenbaum explains. "One of the unique features of the synthetic HDPs is that studies show that pathogens have a difficult time generating resistance to them, because they attack membranes, not proteins. So they might be intrinsically more difficult to become resistant against."

Although Greenbaum's team focused mostly on the chronic red-blood-cell stage of malaria, their HDP-mimic also shows promise against other stages of the disease. "We think that the mimics would be useful as a transmission-blocking therapeutic," Greenbaum says. "In other words, you prevent transmission from human to mosquito and therefore back to human again. We have positive data for those two stages. It's becoming increasingly more important in antimalarial drug development that people think more and more about multistage inhibition."

The next step for Greenbaum's team is to further hone the selectivity and potency of the smHDP compounds, while developing them into drugs that can be orally administered. As Greenbaum explains, practical antimalarials need to be "taken as pills rather than having to be used intravenously, which is not going to be appropriate for treatment in endemic countries, especially in more rural environments."

Co-authors are Melissa S. Love, Melanie G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie B. Freeman, Wenxi Pan, Robert W. Kavash, Michael J. Costanzo, Hyunil Jo, Thomas M. Daly, Dewight R. Williams, M. Anna Kowalska, Lawrence W. Bergman, Mortimer Poncz, William F. DeGrado, Photini Sinnis, and Richard W. Scott.

The research was funded by the National Institutes of Health (R44 AI090762-0; NIHT32GM08076; NIHT32AI007532; R01 AI056840); a Penn TAPITMAT Pilot Program; the Penn Genome Frontiers Institute; and a Gates Grand Challenges Exploration Program.

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The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Melissa?S. Love, Melanie?G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie?B. Freeman, Wenxi Pan, Robert?W. Kavash, Michael?J. Costanzo, Hyunil Jo, Thomas?M. Daly, Dewight?R. Williams, M.?Anna Kowalska, Lawrence?W. Bergman, Mortimer Poncz, William?F. DeGrado, Photini Sinnis, Richard?W. Scott, Doron?C. Greenbaum. Platelet Factor 4 Activity against P.?falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials. Cell Host & Microbe, 2012; 12 (6): 815 DOI: 10.1016/j.chom.2012.10.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Az0RV2Wy5vY/121227130208.htm

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Christine Benvenuto's Husband Became A Woman After 20 Years Of Marriage (EXCERPT)

The following is an excerpt from the new book "Sex Changes: A Memoir of Marriage, Gender, and Moving On" by Christine Benvenuto. Benvenuto's husband decided to live as a woman after 20 years of marriage.

Many people suffer midlife crises. Men in particular seem to be known for them, known for having them out loud and in color, for making decisions that entail the ending of marriages, career metamorphoses, large expenditures of cash, the acquisition of new toys. Women, according to my entirely informal survey, seem to expect themselves to grapple with midlife turmoil by planting a garden, taking up a textile art, or otherwise finding a corner in which to quietly implode. By any measure, Tracey?s crisis was impressive. (I am going to refer to my former husband as Tracey, not because it is his name -- it isn?t --but because it is a gender-neutral name that works before and after and either way.) Tracey never called his midlife crisis a midlife crisis. He represented it as a kind of gender sneeze, an involuntary explosion in reaction to the mounting irritation of inhabiting an identity that didn?t feel like his. In other words, a midlife crisis. It erupted in the middle of our lives. It was a crisis. And like some midlife crises and unlike others, Tracey?s changed everything.

On one level, there really isn?t anything quite like having your husband of twenty-odd years decide to live as a woman, and relatively few people find themselves in that precise situation. But many of us have our lives upended. Illness, death, divorce, other family upheavals. Job loss, geographic dislocation. Life happens. Sooner or later, most of us experience change that is not of our choosing. We fear that we will never regain our equilibrium. We soldier on, racked inside by doubts about whether we are up to the challenges thrown our way. Often, we have no idea how strong we really are. We can?t begin to imagine how happy we may become.

It began with a pair of purple cotton underpants. A woman?s underpants. I pulled them out of the dryer amid the rest of the usual laundry produced by a man, a woman, two children, and one baby. I had never seen these purple underpants before. Tracey came upon me in the basement, standing before the dryer with them in my hand, staring at them. Trying to figure out and at the same time understanding what they were. We stood there, both of us staring at them, in silence.

?Oh, sorry,? he said finally. ?Did I put those in the laundry? I?ve been trying to keep them out of your sight.?

?That?s okay,? I whispered.

This was the first time I had ever seen an item of female clothing that belonged to my husband. It was also the end of Tracey trying to keep women?s clothes out of my sight.

I didn?t want to see. I didn?t want to know. Then again, I was terrified of what I didn?t know. I was afraid of what might be happening behind my back. Of what others might see. Each time he did something new, something further, took another step, made another change, each time I discovered that yet another person had been brought into his confidence, I had to suffer all over again. As if it were possible to stop or even to contain this thing once it had begun. I wanted to understand and yet I didn?t. Understanding meant believing it was happening. A kind of acceptance. I couldn?t accept. I couldn?t. This is one of the hardest things to remember now and to convey: the difficulty I had bending my mind around this thing.

When Tracey announced to the world that he liked to wear women?s clothes and would now do so all the time, he was aggressive, to. He didn?t ask. He told. He did. He assumed a treasure trove, a trousseau, of feminine things, and he eloped with himself.

The unfolding, the ripening, that is female adolescence can be a beautiful thing when it happens to a twelve-or fourteen-year-old girl. When it is embarked upon by a 40-something-year-old man, it is something else again. Female adolescence was Tracey?s way of explaining the process he had entered into, an umbrella term to cover the series of things he was doing to himself. Many young girls experience this period in their lives as hellish; Tracey was gleeful.

Outwardly [our] family continued. We handled together what we had to: home repairs, the scheduling complications entailed by three children. From paying bills to baking birthday cakes, I had always managed much of our domestic lives on my own. Now ?much? gradually became all.

We had dinners together as a family when Tracey was at home, but the noisy conversation that once bubbled over at our table dwindled to a strained trickle. The children witness Tracey?s undisguised misery, felt the tension they couldn?t name. In Tracey?s presence I found there was very little I needed to say. Once I would have chatted about work, the events of my day, the endless pleasures and concerns occasioned by the children. Now the stuff of my life, of the children?s lives, never seemed to grab Tracey?s attention. A single subject absorbed him. When we weren?t talking about that -- and we weren?t, in front of the children -- it was as if Tracey and I had nothing in common.

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Source: http://www.huffingtonpost.com/2012/12/26/christine-benvenuto-sex-changes_n_2330988.html

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